Archive for the ‘Pulmonary Hypertension’ Category

Most common user conditions: Pulmonary hypertension

Wednesday, August 24th, 2011

This week in our most common conditions series, we highlight pulmonary hypertension (PH), which affects more than 215 Healthetreatment members.

This disease, also known as pulmonary arterial hypertension (PAH), is characterized by high blood pressure in the the pulmonary artery (the tube that connects the lungs and the heart). Raised pressure causes the right heart to become enlarged, which is potentially fatal if left untreated. Most of our members who suffer from this illness are female, at 88 percent.

Most symptoms of pulmonary hypertension were given a rating of 4/5 for severity, with the most common being shortness of breath. Nearly 70 percent of Healthetreatment users experienced this disruption in their breathing. More than half reported suffering from heart palpitations, while others also experienced chest pain, fainting, fatigue and malaise.

Some of the most popular treatments for PH are sildenafil (also known by brand names Viagra or Revatio), bosentan (Tracleer) and warfarin (Coumadin). Other treatments that our members have reported include oxygen supplementation, Remodulin, Lasix, Fiolan and tadalafil.

PAH is the most common form of this heart disease, while the idiopathic (IPAH) and familiar (FPAH) forms are not seen as often. The latter two can be difficult to catch in the early stages, as symptoms may resemble asthma and lead to a misdiagnosis, or the patient may not exhibit any symptoms to diagnose until much later. FPAH is the only form of pulmonary hypertension that is known to be caused by genetics. Other forms can be caused by scleroderma, pulmonary embolisms or blood clots in the lungs.

Certain drugs proved ineffective for the treatment of pulmonary hypertension

Thursday, May 26th, 2011

Pulmonary arterial hypertension (PAH) is a heart-related lung condition in which the pulmonary artery (providing the connection between the lungs and heart) experiences high pressure and thus, enlargement of the right ventricle. While treatments like aspirin or simvastatin are often used to relieve the symptoms of heart diseases, research has revealed that these remedies are ineffective for those suffering from PAH.

According to a study performed by the U.S. National Institutes of Health, participants with PAH were either given aspirin, simvastatin, both treatments or a placebo drug to determine whether the medications had any positive effect on the condition. Dr. Steven Kawut, a professor of medicine and epidemiology at the University of Pennsylvania’s School of Medicine, who authored the study, was not expecting the results that came about after six months.

“Surprisingly, we found no evidence that aspirin or simvastatin had beneficial clinical effects in this population,” he said. Ultimately, Kawut determined that patients could take these drugs for their FDA-approved uses, but should not be relied on primarily for the treatment of PAH.

The researcher also emphasized that studies like this are important, as certain “cardiovascular therapies and drugs which appear effective in the laboratory” may not always be effective for human use.

Kuwat and his team presented their findings last week in Denver, Colorado, at the American Thoracic Society conference.